InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGTPBP1

Summary

InnateDB Protein

IDBP-74395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGTPBP1

Protein Name

ATP/GTP binding protein 1

Synonyms

CCP1; NNA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349592

InnateDB Gene

IDBG-74389 (AGTPBP1)

Protein Structure

UniProt Annotation

Function

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004181	metallocarboxypeptidase activity
GO:0005488	binding
GO:0008270	zinc ion binding
GO:0015631	tubulin binding

Biological Process

GO:0001754	eye photoreceptor cell differentiation
GO:0006508	proteolysis
GO:0007005	mitochondrion organization
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021772	olfactory bulb development
GO:0035609	C-terminal protein deglutamylation
GO:0035610	protein side chain deglutamylation
GO:0050905	neuromuscular process