InnateDB Protein
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IDBP-74397.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGTPBP1
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Protein Name
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ATP/GTP binding protein 1
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Synonyms
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CCP1; NNA1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000365251
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InnateDB Gene
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IDBG-74389 (AGTPBP1)
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Protein Structure
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Function |
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000834
Peptidase M14, carboxypeptidase A
IPR016024
Armadillo-type fold
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PFAM |
PF00246
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PRINTS |
PR00765
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PIRSF |
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SMART |
SM00631
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UPW5
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PhosphoSite |
PhosphoSite-Q9UPW5
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TrEMBL |
A0A024R288
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UniProt Splice Variant |
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Entrez Gene |
23287
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UniGene |
Hs.719980
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RefSeq |
NP_056054
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HUGO |
HGNC:17258
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OMIM |
606830
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CCDS |
CCDS6672
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HPRD |
08442
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IMGT |
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EMBL |
AB028958
AK001544
AK022562
AK023280
AK295774
AK299506
AL157882
AL451131
AL833359
BC060815
BX648366
CH471089
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GenPept |
AAH60815
BAA82987
BAA91749
BAB14100
BAB14505
BAG58598
BAG61460
CAH56158
CAH56222
CAH71213
CAH71214
CAH72317
CAH72318
EAW62694
EAW62696
EAW62697
EAW62698
EAW62699
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