InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: A1CF

Summary

InnateDB Protein

IDBP-74467.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

A1CF

Protein Name

APOBEC1 complementation factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282641

InnateDB Gene

IDBG-74457 (A1CF)

Protein Structure

UniProt Annotation

Function

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269PubMed:10669759, ECO:0000269PubMed:10781591, ECO:0000269PubMed:12881431}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269PubMed:10669759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding