InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKG1

Summary

InnateDB Protein

IDBP-74549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKG1

Protein Name

protein kinase, cGMP-dependent, type I

Synonyms

1; AAT8; cGK; cGK 1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; PKG; PRKG1B; PRKGR1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000363097

InnateDB Gene

IDBG-74547 (PRKG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030553	cGMP binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007596	blood coagulation
GO:0030036	actin cytoskeleton organization
GO:0043087	regulation of GTPase activity
GO:0090331	negative regulation of platelet aggregation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000595 Cyclic nucleotide-binding domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002373 cAMP/cGMP-dependent protein kinase
IPR002374 cGMP-dependent kinase
IPR011009 Protein kinase-like domain
IPR016232 cGMP-dependent protein kinase
IPR018490 Cyclic nucleotide-binding-like
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00027
PF00069
PF07714

PRINTS

PR00109
PR00103
PR00104

PIRSF

PIRSF000559

SMART

SM00100
SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References