InnateDB Protein
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IDBP-745960.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SULT1A1
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Protein Name
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Synonyms
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HAST1/HAST2; P-PST; PST; ST1A1; ST1A3; STP; STP1; TSPST1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000457912
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InnateDB Gene
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IDBG-22979 (SULT1A1)
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Protein Structure
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Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. {ECO:0000269PubMed:12471039, ECO:0000269PubMed:16221673}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Liver, lung, adrenal, brain, platelets and skin.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00685
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P50225
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PhosphoSite |
PhosphoSite-P50225
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TrEMBL |
Q9UMT9
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UniProt Splice Variant |
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Entrez Gene |
6817
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UniGene |
Hs.736805
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RefSeq |
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HUGO |
HGNC:11453
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OMIM |
171150
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CCDS |
CCDS32420
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HPRD |
01372
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IMGT |
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EMBL |
AB062428
AC020765
AJ007418
BC000923
BC110887
BT007324
CR608214
L10819
L15346
L19955
L19999
U09031
U26309
U37025
U52852
U54701
U71086
X78283
X84654
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GenPept |
AAA02935
AAA18613
AAA35562
AAA60595
AAA67895
AAA99892
AAB09597
AAB09759
AAC50480
AAC51816
AAH00923
AAI10888
AAP35988
BAB93491
CAA07495
CAA55089
CAA59147
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