Version 5.4
Homo sapiens Protein: CIAPIN1
Summary
InnateDB Protein IDBP-746480.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CIAPIN1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000456114
InnateDB Gene IDBG-33248 (CIAPIN1)
Protein Structure
UniProt Annotation
Function Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1. {ECO:0000250, ECO:0000269PubMed:23596212}.
Subcellular Localization Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space {ECO:0000305}. Note=Imported into mitochondria (in vitro).
Disease Associations
Tissue Specificity Ubiquitously expressed. Highly expressed in heart, liver and pancreas. {ECO:0000269PubMed:14970183}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006915 apoptotic process
GO:0016226 iron-sulfur cluster assembly
GO:0030097 hemopoiesis
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
Protein Structure and Domains
PDB ID
InterPro IPR007785 Anamorsin
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF05093
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6FI81
PhosphoSite PhosphoSite-Q6FI81
TrEMBL H3BTZ8
UniProt Splice Variant
Entrez Gene 57019
UniGene Hs.4900
RefSeq XP_005256118
HUGO HGNC:28050
OMIM 608943
CCDS
HPRD 12338
IMGT
EMBL AC004382 AC009052 AF116609 AF248964 AK292281 AL136613 BC002568 BC024196 BC067303 BC071740 CH471092 CR533545
GenPept AAC24311 AAC24312 AAF71034 AAG44562 AAH02568 AAH24196 AAH67303 AAH71740 BAF84970 CAB66548 CAG38576 EAW82923

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca