InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPRC5B

Summary

InnateDB Protein

IDBP-746808.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPRC5B

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000454727

InnateDB Gene

IDBG-18080 (GPRC5B)

Protein Structure

UniProt Annotation

Function

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10945465}; Multi-pass membrane protein {ECO:0000269PubMed:10945465}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:10945465}; Multi- pass membrane protein {ECO:0000269PubMed:10945465}. Note=Localized in the plasma membrane and perinuclear vesicles.

Disease Associations

Tissue Specificity

Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal chord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach. {ECO:0000269PubMed:10783259, ECO:0000269PubMed:10945465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004930	G-protein coupled receptor activity
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045666	positive regulation of neuron differentiation
GO:0050729	positive regulation of inflammatory response
GO:0060907	positive regulation of macrophage cytokine production
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome