InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DKK1

Summary

InnateDB Protein

IDBP-74686.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DKK1

Protein Name

dickkopf homolog 1 (Xenopus laevis)

Synonyms

DKK-1; SK;

Species

Homo sapiens

Ensembl Protein

ENSP00000363081

InnateDB Gene

IDBG-74684 (DKK1)

Protein Structure

UniProt Annotation

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269PubMed:22000856}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0048019	receptor antagonist activity
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000904	cell morphogenesis involved in differentiation
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0001942	hair follicle development
GO:0002090	regulation of receptor internalization
GO:0007275	multicellular organismal development
GO:0007492	endoderm development
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0030514	negative regulation of BMP signaling pathway
GO:0030900	forebrain development
GO:0031333	negative regulation of protein complex assembly
GO:0032526	response to retinoic acid
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0042662	negative regulation of mesodermal cell fate specification
GO:0042663	regulation of endodermal cell fate specification
GO:0048642	negative regulation of skeletal muscle tissue development
GO:0060323	head morphogenesis
GO:0060325	face morphogenesis
GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0090082	positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:1900116	extracellular negative regulation of signal transduction
GO:1901296	negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment
GO:2000726	negative regulation of cardiac muscle cell differentiation