Version 5.4
Homo sapiens Protein: COX5A
Summary
InnateDB Protein IDBP-746971.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX5A
Protein Name
Synonyms COX; COX-VA; VA;
Species Homo sapiens
Ensembl Protein ENSP00000456386
InnateDB Gene IDBG-22937 (COX5A)
Protein Structure
UniProt Annotation
Function This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Localization Mitochondrion inner membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004129 cytochrome-c oxidase activity
GO:0009055 electron carrier activity
GO:0046872 metal ion binding
Biological Process
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1902600 hydrogen ion transmembrane transport
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003204 Cytochrome c oxidase, subunit Va/VI
PFAM PF02284
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P20674
PhosphoSite PhosphoSite-P20674
TrEMBL Q71UP1
UniProt Splice Variant
Entrez Gene 9377
UniGene Hs.732727
RefSeq
HUGO HGNC:2267
OMIM 603773
CCDS CCDS10273
HPRD 04799
IMGT
EMBL AC125435 AF067635 BC024240 CH471136 CR407649 DQ987236 DQ987237 M22760
GenPept AAA99220 AAC73060 AAH24240 ABK92283 ABK92284 CAG28577 EAW99288

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca