InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZWINT

Summary

InnateDB Protein

IDBP-74821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZWINT

Protein Name

ZW10 interactor

Synonyms

HZwint-1; KNTC2AP; ZWINT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363055

InnateDB Gene

IDBG-74819 (ZWINT)

Protein Structure

UniProt Annotation

Function

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. {ECO:0000269PubMed:15094189, ECO:0000269PubMed:15485811, ECO:0000269PubMed:15824131, ECO:0000269PubMed:16732327}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007093	mitotic cell cycle checkpoint
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051649	establishment of localization in cell

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle