InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA8

Summary

InnateDB Protein

IDBP-74849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA8

Protein Name

heat shock 70kDa protein 8

Synonyms

HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71;

Species

Homo sapiens

Ensembl Protein

ENSP00000227378

InnateDB Gene

IDBG-74847 (HSPA8)

Protein Structure

UniProt Annotation

Function

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. {ECO:0000269PubMed:10722728, ECO:0000269PubMed:11276205, ECO:0000269PubMed:23990462}.

Subcellular Localization

Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11276205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 371 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	371 [view]
Protein-Protein	367 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019899	enzyme binding
GO:0023026	MHC class II protein complex binding
GO:0031072	heat shock protein binding
GO:0042623	ATPase activity, coupled
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006457	protein folding
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006986	response to unfolded protein
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007411	axon guidance
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0042026	protein refolding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0061024	membrane organization
GO:1902904	negative regulation of fibril organization

Cellular Component

GO:0000974	Prp19 complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042470	melanosome
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P11142