InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZFP90

Summary

InnateDB Protein

IDBP-749068.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZFP90

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000460547

InnateDB Gene

IDBG-38475 (ZFP90)

Protein Structure

UniProt Annotation

Function

May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0043392	negative regulation of DNA binding
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated