Version 5.4
Homo sapiens Protein: PAM16
Summary
InnateDB Protein IDBP-750074.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAM16
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000461047
InnateDB Gene IDBG-281532 (PAM16)
Protein Structure
UniProt Annotation
Function Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269PubMed:20053669}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:11750097, ECO:0000269PubMed:20053669}; Peripheral membrane protein {ECO:0000269PubMed:11750097, ECO:0000269PubMed:20053669}; Matrix side {ECO:0000269PubMed:11750097, ECO:0000269PubMed:20053669}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:15704001}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0030150 protein import into mitochondrial matrix
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005744 mitochondrial inner membrane presequence translocase complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3D7
PhosphoSite PhosphoSite-Q9Y3D7
TrEMBL
UniProt Splice Variant
Entrez Gene 51025
UniGene Hs.732947
RefSeq
HUGO HGNC:29679
OMIM 614336
CCDS CCDS10512
HPRD 14798
IMGT
EMBL AF151894 AF349455 AK026514 BC005024 CR457362
GenPept AAD34131 AAH05024 AAL57767 BAB15494 CAG33643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca