InnateDB Protein
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IDBP-75012.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HAT1
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Protein Name
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histone acetyltransferase 1
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Synonyms
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KAT1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264108
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InnateDB Gene
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IDBG-75010 (HAT1)
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Protein Structure
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Function |
Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage. {ECO:0000269PubMed:11585814, ECO:0000269PubMed:20953179, ECO:0000269PubMed:9427644}.
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Subcellular Localization |
Isoform A: Nucleus matrix.Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR016181
Acyl-CoA N-acyltransferase
IPR017380
Histone acetyltransferase type B, catalytic subunit
IPR019467
Histone acetyl transferase HAT1 N-terminal
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PFAM |
PF10394
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PRINTS |
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PIRSF |
PIRSF038084
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O14929
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PhosphoSite |
PhosphoSite-O14929
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8520
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UniGene |
Hs.692684
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RefSeq |
NP_003633
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HUGO |
HGNC:4821
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OMIM |
603053
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CCDS |
CCDS2245
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HPRD |
04339
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IMGT |
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EMBL |
AC015976
AC114745
AF030424
BC018682
BC045673
BC063003
CH471058
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GenPept |
AAC02425
AAH18682
AAH63003
AAX93247
AAY14731
EAX11195
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