InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNG4

Summary

InnateDB Protein

IDBP-750252.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNG4

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000457897

InnateDB Gene

IDBG-44532 (KCNG4)

Protein Structure

UniProt Annotation

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.

Disease Associations

Tissue Specificity

Highly expressed in brain, and at lower levels in liver, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005251	delayed rectifier potassium channel activity

Biological Process

GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex

Protein Structure and Domains

PDB ID

InterPro

IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003969 Potassium channel, voltage dependent, Kv6
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003974 Potassium channel, voltage dependent, Kv3
IPR011333 BTB/POZ fold

PFAM

PF02214

PRINTS

PR00169
PR01492
PR01494
PR01498

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TDN1