Version 5.4
| Homo sapiens Protein: BICC1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-75035.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | BICC1 | ||||||||
| Protein Name | bicaudal C homolog 1 (Drosophila) | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000362993 | ||||||||
| InnateDB Gene | IDBG-75033 (BICC1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269PubMed:21922595}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. | ||||||||
| Disease Associations | Renal dysplasia, cystic (CYSRD) [MIM:601331]: An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts. {ECO:0000269PubMed:21922595}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001660
Sterile alpha motif domain IPR004087 K Homology domain IPR004088 K Homology domain, type 1 IPR011510 Sterile alpha motif, type 2 IPR013761 Sterile alpha motif/pointed domain IPR021129 Sterile alpha motif, type 1 |
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| PFAM |
PF00013
PF13014 PF07647 PF00536 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00454
SM00322 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9H694 | ||||||||
| PhosphoSite | PhosphoSite-Q9H694 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 80114 | ||||||||
| UniGene | Hs.633222 | ||||||||
| RefSeq | NP_001073981 | ||||||||
| HUGO | HGNC:19351 | ||||||||
| OMIM | 614295 | ||||||||
| CCDS | CCDS31206 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK026129 AY726586 | ||||||||
| GenPept | BAB15369 | ||||||||