InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STUB1

Summary

InnateDB Protein

IDBP-751287.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STUB1

Protein Name

Synonyms

CHIP; HSPABP2; NY-CO-7; SCAR16; SDCCAG7; UBOX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000456875

InnateDB Gene

IDBG-8030 (STUB1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. {ECO:0000269PubMed:10330192, ECO:0000269PubMed:11146632, ECO:0000269PubMed:11557750, ECO:0000269PubMed:15466472, ECO:0000269PubMed:19103148, ECO:0000269PubMed:19567782, ECO:0000269PubMed:19713937, ECO:0000269PubMed:23990462}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10330192}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung. {ECO:0000269PubMed:10330192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 331 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	331 [view]
Protein-Protein	328 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0030544	Hsp70 protein binding
GO:0030674	protein binding, bridging
GO:0030911	TPR domain binding
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0051787	misfolded protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016567	protein ubiquitination
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0031943	regulation of glucocorticoid metabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051604	protein maturation
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0071218	cellular response to misfolded protein
GO:0090035	positive regulation of chaperone-mediated protein complex assembly

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031371	ubiquitin conjugating enzyme complex
GO:0042405	nuclear inclusion body
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome