Version 5.4
Homo sapiens Protein: NDRG4
Summary
InnateDB Protein IDBP-751408.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDRG4
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000458113
InnateDB Gene IDBG-34297 (NDRG4)
Protein Structure
UniProt Annotation
Function Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. {ECO:0000250, ECO:0000269PubMed:12755708}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:12755708, ECO:0000269PubMed:19592488}.
Disease Associations
Tissue Specificity Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. {ECO:0000269PubMed:11352569, ECO:0000269PubMed:12755708, ECO:0000269PubMed:19592488}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006950 response to stress
GO:0016049 cell growth
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR004142 NDRG
IPR029058 Alpha/Beta hydrolase fold
PFAM PF03096
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ULP0
PhosphoSite PhosphoSite-Q9ULP0
TrEMBL H3BUK1
UniProt Splice Variant
Entrez Gene 65009
UniGene Hs.729314
RefSeq
HUGO HGNC:14466
OMIM 614463
CCDS
HPRD 14817
IMGT
EMBL AB021172 AB033006 AB044944 AB044945 AB044946 AB044947 AC009118 AF308608 AK055038 AK126574 AK131248 AK296415 AK299949 AK316089 AL136584 BC011795
GenPept AAH11795 AAL08806 BAA86494 BAB20068 BAB20069 BAB20070 BAB20071 BAB20072 BAB20073 BAB20288 BAC86600 BAD18428 BAG51454 BAG59078 BAG61777 BAH14460 CAB66519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca