Version 5.4
Homo sapiens Protein: OGFOD1
Summary
InnateDB Protein IDBP-751946.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OGFOD1
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000457258
InnateDB Gene IDBG-31955 (OGFOD1)
Protein Structure
UniProt Annotation
Function Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit RPS23, thereby regulating protein translation termination efficiency. Involved in stress granule formation. {ECO:0000269PubMed:20154146, ECO:0000269PubMed:24550447, ECO:0000269PubMed:24550462}.
Subcellular Localization Isoform 1: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.Isoform 2: Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
GO:0031543 peptidyl-proline dioxygenase activity
GO:0031544 peptidyl-proline 3-dioxygenase activity
Biological Process
GO:0006449 regulation of translational termination
GO:0008283 cell proliferation
GO:0018126 protein hydroxylation
GO:0019511 peptidyl-proline hydroxylation
GO:0034063 stress granule assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
Protein Structure and Domains
PDB ID
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR019601 Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain
PFAM PF10637
PRINTS
PIRSF
SMART SM00702
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N543
PhosphoSite PhosphoSite-Q8N543
TrEMBL H3BUA6
UniProt Splice Variant
Entrez Gene 55239
UniGene Hs.682310
RefSeq NP_060703
HUGO HGNC:25585
OMIM 615857
CCDS CCDS10761
HPRD 08553
IMGT
EMBL AB046832 AC092140 AK001688 AK022130 AK022752 AK024314 BC032919
GenPept AAH32919 BAA91838 BAB13438 BAB13967 BAB14226 BAB14880

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca