Version 5.4
Homo sapiens Protein: ACSM5
Summary
InnateDB Protein IDBP-752067.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACSM5
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000460112
InnateDB Gene IDBG-18360 (ACSM5)
Protein Structure
UniProt Annotation
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in kidney and liver. {ECO:0000269PubMed:12654705}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR000873 AMP-dependent synthetase/ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NUN0
PhosphoSite PhosphoSite-Q6NUN0
TrEMBL
UniProt Splice Variant
Entrez Gene 54988
UniGene Hs.659606
RefSeq
HUGO HGNC:26060
OMIM 614361
CCDS
HPRD 08627
IMGT
EMBL AC137056 AK000588 BC013753 BC016703 BC068516
GenPept AAH13753 AAH16703 AAH68516 BAA91273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca