InnateDB Protein
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IDBP-752781.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CLUAP1
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Protein Name
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Synonyms
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CFAP22; FAP22;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000460850
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InnateDB Gene
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IDBG-12079 (CLUAP1)
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Protein Structure
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Function |
Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Cell projection, cilium.
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Disease Associations |
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Tissue Specificity |
Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines. {ECO:0000269PubMed:15480429, ECO:0000269PubMed:17203229}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001715
Calponin homology domain
IPR019366
Clusterin-associated protein-1
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PFAM |
PF00307
PF10234
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PRINTS |
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PIRSF |
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SMART |
SM00033
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AJ1
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PhosphoSite |
PhosphoSite-Q96AJ1
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TrEMBL |
I3L487
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UniProt Splice Variant |
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Entrez Gene |
23059
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UniGene |
Hs.742198
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RefSeq |
NP_055856
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HUGO |
HGNC:19009
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OMIM |
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CCDS |
CCDS32381
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HPRD |
10013
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IMGT |
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EMBL |
AB014543
AB089691
AC004224
AC004494
AK023319
AK023359
BC017070
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GenPept |
AAH17070
BAA31618
BAB14523
BAB14542
BAD44779
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