Version 5.4
Homo sapiens Protein: KAT8
Summary
InnateDB Protein IDBP-753077.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT8
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000456933
InnateDB Gene IDBG-27798 (KAT8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 59 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016407 acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0035064 methylated histone binding
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046872 metal ion binding
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016573 histone acetylation
GO:0030099 myeloid cell differentiation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031965 nuclear membrane
GO:0071339 MLL1 complex
GO:0072487 MSL complex
Protein Structure and Domains
PDB ID
InterPro IPR000953 Chromo domain/shadow
IPR002717 MOZ/SAS-like protein
IPR016181 Acyl-CoA N-acyltransferase
IPR016197 Chromo domain-like
IPR025995 RNA binding activity-knot of a chromodomain
PFAM PF01853
PF11717
PRINTS
PIRSF
SMART SM00298
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H7Z6
PhosphoSite PhosphoSite-Q9H7Z6
TrEMBL
UniProt Splice Variant
Entrez Gene 84148
UniGene Hs.640371
RefSeq
HUGO HGNC:17933
OMIM 609912
CCDS CCDS10706
HPRD 11381
IMGT
EMBL AC009088 AC135050 AF217501 AF260665 AF289578 AK021872 AK024102 AK291106 AL050395 BC037773 CH471192
GenPept AAF72665 AAH37773 AAL55762 AAL56648 BAB13924 BAB14827 BAF83795 CAH56416 EAW52157 EAW52158

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca