InnateDB Protein
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IDBP-75466.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FEZ1
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Protein Name
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fasciculation and elongation protein zeta 1 (zygin I)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278919
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InnateDB Gene
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IDBG-75464 (FEZ1)
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Protein Structure
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Function |
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269PubMed:20812761, ECO:0000269PubMed:22354037}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:18439996}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Mainly expressed in brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
77
[view]
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Protein-Protein |
77
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011680
Fasciculation and elongation protein zeta, FEZ
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PFAM |
PF07763
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99689
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PhosphoSite |
PhosphoSite-Q99689
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TrEMBL |
E9PNH2
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UniProt Splice Variant |
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Entrez Gene |
9638
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UniGene |
Hs.732083
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RefSeq |
NP_005094
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HUGO |
HGNC:3659
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OMIM |
604825
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CCDS |
CCDS31716
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HPRD |
09212
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IMGT |
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EMBL |
AP000708
BC009545
CR456817
CR541954
U60060
U60062
U69139
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GenPept |
AAB40660
AAC51282
AAC51284
AAH09545
CAG33098
CAG46752
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