InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANAPC11

Summary

InnateDB Protein

IDBP-757890.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANAPC11

Protein Name

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000464615

InnateDB Gene

IDBG-72756 (ANAPC11)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269PubMed:11739784, ECO:0000269PubMed:18485873}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11573242}. Nucleus {ECO:0000269PubMed:11573242}.

Disease Associations

Tissue Specificity

Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. {ECO:0000269PubMed:11573242}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.

Experimentally validated
Total	43 [view]
Protein-Protein	43 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007094	mitotic spindle assembly checkpoint
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0070979	protein K11-linked ubiquitination