Homo sapiens Protein: BRCA1
Summary
InnateDB Protein IDBP-759502.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCA1
Protein Name
Synonyms BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53;
Species Homo sapiens
Ensembl Protein ENSP00000465818
InnateDB Gene IDBG-52172 (BRCA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 625 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 625 [view]
Protein-Protein 603 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001357 BRCT domain
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)
PFAM PF00533
PF12738
PRINTS PR00493
PIRSF PIRSF001734
SMART SM00292
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9NQR3
UniProt Splice Variant
Entrez Gene 672
UniGene Hs.622171
RefSeq
HUGO HGNC:1100
OMIM 113705
CCDS
HPRD 00218
IMGT
EMBL AC135721 AF284812 AF507076 AF507078 AY093485 AY093486 AY093487 AY093489 AY093490 AY093493 DQ333386 FJ940752
GenPept AAF97939 AAM18219 AAM18220 AAM18221 AAM18222 AAM18223 AAM18226 AAN61423 AAN61425 ABC59810 ACR33809