Version 5.4
Homo sapiens Protein: TIMP2
Summary
InnateDB Protein IDBP-760413.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMP2
Protein Name
Synonyms CSC-21K; DDC8;
Species Homo sapiens
Ensembl Protein ENSP00000464930
InnateDB Gene IDBG-70963 (TIMP2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001134 Netrin domain
IPR001820 Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
PFAM PF00965
PRINTS
PIRSF
SMART SM00206
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL K7EL90
UniProt Splice Variant
Entrez Gene 7077
UniGene Hs.633514
RefSeq
HUGO HGNC:11821
OMIM 188825
CCDS
HPRD 01784
IMGT
EMBL AC022966 AC100788
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca