InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKACA

Summary

InnateDB Protein

IDBP-760734.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKACA

Protein Name

Synonyms

PKACA;

Species

Homo sapiens

Ensembl Protein

ENSP00000466651

InnateDB Gene

IDBG-32929 (PRKACA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	162 [view]
Protein-Protein	160 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0034237	protein kinase A regulatory subunit binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0002027	regulation of heart rate
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006112	energy reserve metabolic process
GO:0006468	protein phosphorylation
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0018105	peptidyl-serine phosphorylation
GO:0019433	triglyceride catabolic process
GO:0034199	activation of protein kinase A activity
GO:0035556	intracellular signal transduction
GO:0035584	calcium-mediated signaling using intracellular calcium source
GO:0043393	regulation of protein binding
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045667	regulation of osteoblast differentiation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048240	sperm capacitation
GO:0050796	regulation of insulin secretion
GO:0051480	cytosolic calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0061136	regulation of proteasomal protein catabolic process
GO:0071158	positive regulation of cell cycle arrest
GO:0071333	cellular response to glucose stimulus
GO:0071377	cellular response to glucagon stimulus
GO:0071872	cellular response to epinephrine stimulus
GO:0086064	cell communication by electrical coupling involved in cardiac conduction
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0005952	cAMP-dependent protein kinase complex
GO:0016020	membrane
GO:0031588	AMP-activated protein kinase complex
GO:0034704	calcium channel complex
GO:0070062	extracellular vesicular exosome
GO:0097225	sperm midpiece

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt