InnateDB Protein
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IDBP-760819.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PIK3R5
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Protein Name
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Synonyms
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F730038I15Rik; FOAP-2; p101; P101-PI3K;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000462433
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InnateDB Gene
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IDBG-29574 (PIK3R5)
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Protein Structure
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Function |
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. {ECO:0000269PubMed:22065524}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. {ECO:0000269PubMed:15797027, ECO:0000269PubMed:22065524}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0031683
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G-protein beta/gamma-subunit complex binding
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GO:0046935
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1-phosphatidylinositol-3-kinase regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019522
Phosphoinositide 3-kinase regulatory subunit 5/6
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PFAM |
PF10486
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8WYR1
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PhosphoSite |
PhosphoSite-Q8WYR1
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TrEMBL |
L7RT34
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UniProt Splice Variant |
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Entrez Gene |
23533
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UniGene |
Hs.738684
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RefSeq |
NP_055123
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HUGO |
HGNC:30035
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OMIM |
611317
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CCDS |
CCDS11147
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HPRD |
11433
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IMGT |
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EMBL |
AB028925
AC002091
AC003695
AF128881
AY725851
AY725852
AY725853
AY725854
BC028212
CH471108
EU332864
JX512456
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GenPept |
AAD33397
AAH28212
AAW63121
AAW63122
AAW63123
AAW63124
ABY87553
AGC09603
BAB82464
EAW90035
EAW90036
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