InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNM2

Summary

InnateDB Protein

IDBP-761386.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM2

Protein Name

Synonyms

CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; DYNII; LCCS5;

Species

Homo sapiens

Ensembl Protein

ENSP00000468734

InnateDB Gene

IDBG-28168 (DNM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	116 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008017	microtubule binding
GO:0019899	enzyme binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0008219	cell death
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0043065	positive regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046209	nitric oxide metabolic process
GO:0048489	synaptic vesicle transport
GO:0050999	regulation of nitric-oxide synthase activity
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030496	midbody
GO:0030666	endocytic vesicle membrane
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001849 Pleckstrin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00169
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00233
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt