InnateDB Protein
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IDBP-761434.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPTOR
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000460136
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InnateDB Gene
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IDBG-71820 (RPTOR)
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Protein Structure
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Function |
Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. {ECO:0000269PubMed:12150925, ECO:0000269PubMed:12150926, ECO:0000269PubMed:23727834}.
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Subcellular Localization |
Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
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Disease Associations |
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Tissue Specificity |
Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen. {ECO:0000269PubMed:12150925, ECO:0000269PubMed:12408816}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 127 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
127
[view]
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Protein-Protein |
127
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N122
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PhosphoSite |
PhosphoSite-Q8N122
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
57521
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UniGene |
Hs.133044
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RefSeq |
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HUGO |
HGNC:30287
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OMIM |
607130
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CCDS |
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HPRD |
06184
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IMGT |
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EMBL |
AB037724
AB082951
AC016245
AC109327
AC127496
AC133012
AY090663
BC025180
BC033258
BC064515
BC136652
BC136654
CH471099
GQ183898
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GenPept |
AAH25180
AAH33258
AAH64515
AAI36653
AAI36655
AAM09075
ACS44766
BAA92541
BAC06490
EAW89618
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