Version 5.4
Homo sapiens Protein: AMZ2
Summary
InnateDB Protein IDBP-761939.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMZ2
Protein Name
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000464133
InnateDB Gene IDBG-65751 (AMZ2)
Protein Structure
UniProt Annotation
Function Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2. {ECO:0000269PubMed:15972818}.
Subcellular Localization
Disease Associations
Tissue Specificity Predominantly expressed in heart and testis. Also expressed at lower levels in kidney, liver, pancreas, lung, brain and placenta. Expressed in fetal tissues such as kidney, liver, lung and brain. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS). {ECO:0000269PubMed:15972818, ECO:0000269PubMed:17074343}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR012962 Peptidase M54, archaemetzincin
PFAM PF07998
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86W34
PhosphoSite PhosphoSite-Q86W34
TrEMBL J3QLK6
UniProt Splice Variant
Entrez Gene 51321
UniGene Hs.293560
RefSeq XP_005257489
HUGO HGNC:28041
OMIM 615169
CCDS CCDS11674
HPRD 14237
IMGT
EMBL AC005332 AF208856 AJ635358 AK090981 AK126146 BC050709 BC056271 CH471099
GenPept AAF64270 AAH50709 AAH56271 BAC86462 BAG52256 CAG25750 EAW89050

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca