InnateDB Protein
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IDBP-762465.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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XAF1
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000458229
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InnateDB Gene
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IDBG-22619 (XAF1)
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Protein Structure
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Function |
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. {ECO:0000269PubMed:11175744, ECO:0000269PubMed:12029096, ECO:0000269PubMed:16432762, ECO:0000269PubMed:17329253, ECO:0000269PubMed:17613533}.
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Subcellular Localization |
Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.Isoform 1: Nucleus.Isoform 5: Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level). {ECO:0000269PubMed:11175744, ECO:0000269PubMed:16343440, ECO:0000269PubMed:17329253, ECO:0000269PubMed:17570219}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001293
Zinc finger, TRAF-type
IPR008974
TRAF-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6GPH4
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PhosphoSite |
PhosphoSite-Q6GPH4
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TrEMBL |
I3L3D9
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UniProt Splice Variant |
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Entrez Gene |
54739
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UniGene |
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RefSeq |
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HUGO |
HGNC:30932
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OMIM |
606717
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CCDS |
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HPRD |
06978
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IMGT |
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EMBL |
AC034305
AK290276
AK292710
AK292848
BC032776
BC073156
BX649188
CH471108
EF028165
EF028166
X99699
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GenPept |
AAH32776
AAH73156
ABM74556
ABM74557
BAF82965
BAF85399
BAF85537
CAA68030
CAE46206
EAW90288
EAW90289
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