InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIK3R2

Summary

InnateDB Protein

IDBP-762537.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3R2

Protein Name

Synonyms

MPPH; MPPH1; p85; p85-BETA; P85B;

Species

Homo sapiens

Ensembl Protein

ENSP00000471914

InnateDB Gene

IDBG-729145 (PIK3R2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0030971	receptor tyrosine kinase binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005942	phosphatidylinositol 3-kinase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00017
PF14633
PF00018
PF14604

PRINTS

PR00401
PR00452
PR00678

PIRSF

SMART

SM00324
SM00252
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt