InnateDB Protein
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IDBP-763194.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EGLN2
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Protein Name
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000472414
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InnateDB Gene
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IDBG-728297 (EGLN2)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
|
Protein-Protein |
26
[view]
|
Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005506
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iron ion binding
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GO:0005515
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protein binding
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GO:0008198
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ferrous iron binding
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GO:0016491
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oxidoreductase activity
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GO:0016705
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
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GO:0016706
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
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GO:0019826
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oxygen sensor activity
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GO:0031418
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L-ascorbic acid binding
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GO:0031545
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peptidyl-proline 4-dioxygenase activity
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Biological Process |
GO:0001558
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regulation of cell growth
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GO:0001666
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response to hypoxia
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GO:0018401
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peptidyl-proline hydroxylation to 4-hydroxy-L-proline
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GO:0030520
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intracellular estrogen receptor signaling pathway
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GO:0043523
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regulation of neuron apoptotic process
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GO:0045454
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cell redox homeostasis
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GO:0045732
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positive regulation of protein catabolic process
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GO:0055114
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oxidation-reduction process
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GO:0061418
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regulation of transcription from RNA polymerase II promoter in response to hypoxia
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GO:0071456
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cellular response to hypoxia
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Cellular Component |
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PDB ID |
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InterPro |
IPR005123
Oxoglutarate/iron-dependent dioxygenase
IPR006620
Prolyl 4-hydroxylase, alpha subunit
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PFAM |
PF03171
PF13640
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PRINTS |
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PIRSF |
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SMART |
SM00702
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TIGRFAMs |
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Modification |
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SwissProt |
Q96KS0
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PhosphoSite |
PhosphoSite-Q96KS0
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TrEMBL |
M0R1A3
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UniProt Splice Variant |
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Entrez Gene |
112398
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UniGene |
Hs.515417
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RefSeq |
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HUGO |
HGNC:14660
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OMIM |
606424
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CCDS |
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HPRD |
06970
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IMGT |
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EMBL |
AC008537
AJ310544
AK291385
AL832506
AY040565
BC001723
BC036051
CH471126
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GenPept |
AAH01723
AAH36051
AAK82943
BAF84074
CAC42510
EAW57008
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