Version 5.4
Homo sapiens Protein: DPH1
Summary
InnateDB Protein IDBP-763496.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH1
Protein Name
Synonyms DPH2L; DPH2L1; OVCA1;
Species Homo sapiens
Ensembl Protein ENSP00000458726
InnateDB Gene IDBG-15935 (DPH1)
Protein Structure
UniProt Annotation
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10519411}. Cytoplasm {ECO:0000269PubMed:10519411}. Note=Punctate, primarily perinuclear localization.
Disease Associations
Tissue Specificity Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors. {ECO:0000269PubMed:10519411, ECO:0000269PubMed:8616839}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006412 translation
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002728 Diphthamide synthesis, DPH1/DPH2
IPR016435 Diphthamide synthesis, eukaryotic DPH1/archaeal DPH2
PFAM PF01866
PRINTS
PIRSF PIRSF004967
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZG8
PhosphoSite PhosphoSite-Q9BZG8
TrEMBL V9GYS2
UniProt Splice Variant
Entrez Gene 1801
UniGene Hs.664161
RefSeq
HUGO HGNC:3003
OMIM 603527
CCDS
HPRD 04634
IMGT
EMBL AC090617 AC099684 AF321876 AK090530 BC003099 BC096088 BT019878 CH471108 S81752 U34880
GenPept AAB36297 AAD10198 AAH03099 AAH96088 AAK13428 AAV38681 BAG52179 EAW90567 EAW90569

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca