InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP4K1

Summary

InnateDB Protein

IDBP-765410.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K1

Protein Name

Synonyms

HPK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000465039

InnateDB Gene

IDBG-49296 (MAP4K1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0007257	activation of JUN kinase activity
GO:0008283	cell proliferation
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt