Version 5.4
Homo sapiens Protein: PKIG
Summary
InnateDB Protein IDBP-76755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKIG
Protein Name protein kinase (cAMP-dependent, catalytic) inhibitor gamma
Synonyms PKI-gamma;
Species Homo sapiens
Ensembl Protein ENSP00000361985
InnateDB Gene IDBG-76749 (PKIG)
Protein Structure
UniProt Annotation
Function Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004862 cAMP-dependent protein kinase inhibitor activity
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR004171 cAMP-dependent protein kinase inhibitor
PFAM PF02827
PRINTS
PIRSF PIRSF001667
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2B9
PhosphoSite PhosphoSite-Q9Y2B9
TrEMBL Q549H9
UniProt Splice Variant
Entrez Gene 11142
UniGene Hs.472831
RefSeq NP_008997
HUGO HGNC:9019
OMIM 604932
CCDS CCDS13334
HPRD 05379
IMGT
EMBL AB019517 AF115966 AF182032 AK312048 BC104256 BC104257 CH471077 Z97053
GenPept AAD55445 AAI04257 AAI04258 AAP97238 BAA77336 BAG34984 CAC18874 EAW75908 EAW75910 EAW75911 EAW75912 EAW75913 EAW75914

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca