Version 5.4
Homo sapiens Protein: C9orf3
Summary
InnateDB Protein IDBP-76967.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C9orf3
Protein Name chromosome 9 open reading frame 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364464
InnateDB Gene IDBG-76959 (C9orf3)
Protein Structure
UniProt Annotation
Function Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. {ECO:0000269PubMed:15687497}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney. {ECO:0000269PubMed:15687497}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0005488 binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0019370 leukotriene biosynthetic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold
PFAM PF01433
PF09127
PRINTS PR00756
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6M6
PhosphoSite PhosphoSite-Q8N6M6
TrEMBL X6RBX4
UniProt Splice Variant
Entrez Gene 84909
UniGene Hs.680988
RefSeq NP_001180258
HUGO HGNC:1361
OMIM
CCDS CCDS55328
HPRD 07476
IMGT
EMBL AJ560639 AK027581 AK057450 AK296782 AL157936 AL353768 AL354893 AL807757 BC020194 BC029616 CH471174
GenPept AAH20194 AAH29616 BAB55210 BAB71491 BAG59360 CAD90259 CAI13037 CAI13038 CAI13039 CAI13040 CAI13041 CAI41124 CAI41125 CAI41126 CAI41127 CAI41325 CAI41326 CAI41327 EAW92618 EAW92619 EAW92620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca