InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIFM2

Summary

InnateDB Protein

IDBP-77224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIFM2

Protein Name

apoptosis-inducing factor, mitochondrion-associated, 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000312370

InnateDB Gene

IDBG-77220 (AIFM2)

Protein Structure

UniProt Annotation

Function

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269PubMed:11980907, ECO:0000269PubMed:12135761, ECO:0000269PubMed:15958387}.

Subcellular Localization

Cytoplasm. Mitochondrion outer membrane.

Disease Associations

Tissue Specificity

Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269PubMed:12135761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0043065	positive regulation of apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR003042 Aromatic-ring hydroxylase-like
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF07992

PRINTS

PR00469
PR00420
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BRQ8