InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSMA3

Summary

InnateDB Protein

IDBP-7751.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSMA3

Protein Name

proteasome (prosome, macropain) subunit, alpha type, 3

Synonyms

HC8; PSC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000216455

InnateDB Gene

IDBG-7749 (PSMA3)

Protein Structure

UniProt Annotation

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269PubMed:11350925, ECO:0000269PubMed:17499743}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 225 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	225 [view]
Protein-Protein	224 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004298	threonine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006915	apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603	proteolysis involved in cellular protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005839	proteasome core complex
GO:0019773	proteasome core complex, alpha-subunit complex
GO:0070062	extracellular vesicular exosome