Version 5.4
Homo sapiens Protein: HECW2
Summary
InnateDB Protein IDBP-77772.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HECW2
Protein Name HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260983
InnateDB Gene IDBG-77770 (HECW2)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. {ECO:0000269PubMed:12890487}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in adult brain, lung and heart. {ECO:0000269PubMed:12890487}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 286 experimentally validated interaction(s) in this database.
Experimentally validated
Total 286 [view]
Protein-Protein 286 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000569 HECT
IPR001202 WW domain
PFAM PF00168
PF00632
PF00397
PRINTS PR00360
PIRSF
SMART SM00239
SM00119
SM00456
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2P5
PhosphoSite PhosphoSite-Q9P2P5
TrEMBL C9JPI9
UniProt Splice Variant
Entrez Gene 57520
UniGene Hs.654742
RefSeq NP_065811
HUGO HGNC:29853
OMIM
CCDS CCDS33354
HPRD 17099
IMGT
EMBL AB037722 AC020571 AC068544 AC073905 AC074090 AC093379 AL390186 BC117194 BC117198 CR749424
GenPept AAI17195 AAI17199 BAA92539 CAB99103 CAH18262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca