Version 5.4
Homo sapiens Protein: GTF3C3
Summary
InnateDB Protein IDBP-77825.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF3C3
Protein Name general transcription factor IIIC, polypeptide 3, 102kDa
Synonyms TFIIIC102; TFiiiC2-102; TFIIICgamma;
Species Homo sapiens
Ensembl Protein ENSP00000263956
InnateDB Gene IDBG-77823 (GTF3C3)
Protein Structure
UniProt Annotation
Function Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0010467 gene expression
GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter
GO:0042797 tRNA transcription from RNA polymerase III promoter
Cellular Component
GO:0000127 transcription factor TFIIIC complex
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y5Q9
PhosphoSite PhosphoSite-Q9Y5Q9
TrEMBL
UniProt Splice Variant
Entrez Gene 9330
UniGene Hs.737375
RefSeq NP_036218
HUGO HGNC:4666
OMIM 604888
CCDS CCDS2316
HPRD 11997
IMGT
EMBL AC012486 AF133123 AF465407 AK027050 AK314718 AL137453 BC015995 BC043347 CH471063
GenPept AAD41475 AAH15995 AAH43347 AAL73493 AAX88853 BAB15638 BAG37262 CAB70745 EAW70132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca