Version 5.4
Homo sapiens Protein: ECD
Summary
InnateDB Protein IDBP-78209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECD
Protein Name ecdysoneless homolog (Drosophila)
Synonyms GCR2; HSGT1;
Species Homo sapiens
Ensembl Protein ENSP00000362070
InnateDB Gene IDBG-78207 (ECD)
Protein Structure
UniProt Annotation
Function Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes. {ECO:0000269PubMed:16849563, ECO:0000269PubMed:9928932}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16849563}. Nucleus {ECO:0000269PubMed:16849563}.
Disease Associations
Tissue Specificity Highly expressed in muscle and heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0006110 regulation of glycolytic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR010770 SGT1
PFAM PF07093
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95905
PhosphoSite PhosphoSite-O95905
TrEMBL C9J316
UniProt Splice Variant
Entrez Gene 11319
UniGene Hs.734299
RefSeq NP_009196
HUGO HGNC:17029
OMIM
CCDS CCDS7321
HPRD 11032
IMGT
EMBL AC016394 AK225519 AK315711 BC000721 D88208
GenPept AAH00721 BAA75199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca