Version 5.4
Homo sapiens Protein: SGOL2
Summary
InnateDB Protein IDBP-78214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGOL2
Protein Name shugoshin-like 2 (S. pombe)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000350447
InnateDB Gene IDBG-78212 (SGOL2)
Protein Structure
UniProt Annotation
Function Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. {ECO:0000250, ECO:0000269PubMed:16541025, ECO:0000269PubMed:17485487}.
Subcellular Localization Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore {ECO:0000250}. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity). In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and AUKRB. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0051754 meiotic sister chromatid cohesion, centromeric
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030892 mitotic cohesin complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q562F6
PhosphoSite PhosphoSite-Q562F6
TrEMBL C9JW92
UniProt Splice Variant
Entrez Gene 151246
UniGene Hs.667938
RefSeq NP_689737
HUGO HGNC:30812
OMIM 612425
CCDS CCDS42796
HPRD 11555
IMGT
EMBL AC012459 AC080164 AK057940 AK095291 AY094614 BC035764 BC048349 BC092412 BX647433
GenPept AAH35764 AAH48349 AAH92412 AAM21971 AAY24264 AAY24310 BAB71617 BAC04524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca