Version 5.4
Homo sapiens Protein: APOM
Summary
InnateDB Protein IDBP-78466.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOM
Protein Name apolipoprotein M
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000365081
InnateDB Gene IDBG-78460 (APOM)
Protein Structure
UniProt Annotation
Function Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. {ECO:0000269PubMed:17525477, ECO:0000269PubMed:19733574}.
Subcellular Localization Secreted {ECO:0000269PubMed:17525477, ECO:0000269PubMed:18279674, ECO:0000269PubMed:18460466}. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).
Disease Associations
Tissue Specificity Plasma protein. Expressed in liver and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005319 lipid transporter activity
GO:0005543 phospholipid binding
GO:0016209 antioxidant activity
Biological Process
GO:0009749 response to glucose
GO:0033344 cholesterol efflux
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034384 high-density lipoprotein particle clearance
GO:0034445 negative regulation of plasma lipoprotein particle oxidation
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034365 discoidal high-density lipoprotein particle
GO:0034366 spherical high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011038 Calycin-like
IPR022734 Apolipoprotein M
PFAM PF11032
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95445
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 55937
UniGene
RefSeq NP_061974
HUGO HGNC:13916
OMIM 606907
CCDS CCDS4710
HPRD 06068
IMGT
EMBL AF118393 AF129756 AF161454 AJ245434 AL662801 AL670886 AL805934 BA000025 BC020683 BX511262 CH471081 CN428415 CR354443 CR753842 CR759761
GenPept AAD11443 AAD18084 AAF29014 AAH20683 BAB63389 CAB51604 CAI17788 CAI18319 CAI18511 CAI18513 CAM45814 CAM45816 CAQ06561 CAQ06563 CAQ06991 CAQ06993 CAQ10868 CAQ10870 EAX03461 EAX03463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca