Version 5.4
Homo sapiens Protein: TEX10
Summary
InnateDB Protein IDBP-78752.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEX10
Protein Name testis expressed 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000364037
InnateDB Gene IDBG-78750 (TEX10)
Protein Structure
UniProt Annotation
Function Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {ECO:0000269PubMed:22872859}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus membrane {ECO:0000269PubMed:12429849}; Multi-pass membrane protein {ECO:0000269PubMed:12429849}. Nucleus, nucleolus {ECO:0000269PubMed:12429849}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0071339 MLL1 complex
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
IPR021133 HEAT, type 2
IPR024679 Pre-rRNA-processing protein IPI1/Testis-expressed sequence 10 protein
PFAM PF12333
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXF1
PhosphoSite PhosphoSite-Q9NXF1
TrEMBL A0A024R169
UniProt Splice Variant
Entrez Gene 54881
UniGene Hs.494648
RefSeq NP_060216
HUGO HGNC:25988
OMIM
CCDS CCDS6748
HPRD 15489
IMGT
EMBL AB060968 AK000294 AK302619 AL353805 AL445214 AY598337 BC030652 CH471105
GenPept AAH30652 AAT06748 BAA91062 BAB87845 BAG63864 CAI12537 CAI12538 CAI39742 CAI39743 EAW58927 EAW58928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca