InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprc

Summary

InnateDB Protein

IDBP-788491.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprc

Protein Name

protein tyrosine phosphatase, receptor type, C

Synonyms

B220; Cd45; CD45R; L-CA; loc; Ly-5; Lyt-4; T200;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000138350

InnateDB Gene

IDBG-195821 (Ptprc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016791	phosphatase activity
GO:0019901	protein kinase binding
GO:0043395	heparan sulfate proteoglycan binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001915	negative regulation of T cell mediated cytotoxicity
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002378	immunoglobulin biosynthetic process
GO:0002711	positive regulation of T cell mediated immunity
GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159	leukocyte cell-cell adhesion
GO:0010332	response to gamma radiation
GO:0016311	dephosphorylation
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0031953	negative regulation of protein autophosphorylation
GO:0034113	heterotypic cell-cell adhesion
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042098	T cell proliferation
GO:0042100	B cell proliferation
GO:0042102	positive regulation of T cell proliferation
GO:0043410	positive regulation of MAPK cascade
GO:0044770	cell cycle phase transition
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045577	regulation of B cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0048539	bone marrow development
GO:0048864	stem cell development
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852	T cell receptor signaling pathway
GO:0050853	B cell receptor signaling pathway
GO:0050855	regulation of B cell receptor signaling pathway
GO:0050857	positive regulation of antigen receptor-mediated signaling pathway
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:2000473	positive regulation of hematopoietic stem cell migration
GO:2000648	positive regulation of stem cell proliferation
GO:2001236	regulation of extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005925	focal adhesion
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:97810

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR016335 Leukocyte common antigen
IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF12567
PF12453

PRINTS

PR00700

PIRSF

PIRSF002004

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References