InnateDB Protein
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IDBP-78857.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NCOA5
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Protein Name
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nuclear receptor coactivator 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000290231
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InnateDB Gene
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IDBG-78855 (NCOA5)
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Protein Structure
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Function |
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269PubMed:15073177}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004154
Anticodon-binding
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PFAM |
PF03129
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HCD5
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PhosphoSite |
PhosphoSite-Q9HCD5
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TrEMBL |
Q5JY17
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UniProt Splice Variant |
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Entrez Gene |
57727
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UniGene |
Hs.654991
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RefSeq |
NP_066018
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HUGO |
HGNC:15909
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OMIM |
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CCDS |
CCDS13392
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HPRD |
14813
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IMGT |
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EMBL |
AB046857
AF230533
AF470686
AL035662
AL162458
BC140836
BC151133
CH471077
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GenPept |
AAG36793
AAI40837
AAI51134
AAO33457
BAB13463
CAH74052
CAI42972
EAW75765
EAW75769
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