InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myc

Summary

InnateDB Protein

IDBP-788590.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myc

Protein Name

myelocytomatosis oncogene

Synonyms

AU016757; bHLHe39; Myc2; Niard; Nird;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000140760

InnateDB Gene

IDBG-144556 (Myc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 676 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	26 [view]
Protein-DNA	38 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	676 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001783	B cell apoptotic process
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002082	regulation of oxidative phosphorylation
GO:0002904	positive regulation of B cell apoptotic process
GO:0006006	glucose metabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006848	pyruvate transport
GO:0006865	amino acid transport
GO:0006879	cellular iron ion homeostasis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007007	inner mitochondrial membrane organization
GO:0007346	regulation of mitotic cell cycle
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009100	glycoprotein metabolic process
GO:0009314	response to radiation
GO:0009611	response to wounding
GO:0009812	flavonoid metabolic process
GO:0010332	response to gamma radiation
GO:0010468	regulation of gene expression
GO:0010918	positive regulation of mitochondrial membrane potential
GO:0016055	Wnt signaling pathway
GO:0016485	protein processing
GO:0019087	transformation of host cell by virus
GO:0021854	hypothalamus development
GO:0032091	negative regulation of protein binding
GO:0032204	regulation of telomere maintenance
GO:0032355	response to estradiol
GO:0035690	cellular response to drug
GO:0035914	skeletal muscle cell differentiation
GO:0042474	middle ear morphogenesis
GO:0042981	regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043279	response to alkaloid
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043473	pigmentation
GO:0044330	canonical Wnt signaling pathway involved in positive regulation of wound healing
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0045023	G0 to G1 transition
GO:0045656	negative regulation of monocyte differentiation
GO:0045787	positive regulation of cell cycle
GO:0045821	positive regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046325	negative regulation of glucose import
GO:0046722	lactic acid secretion
GO:0048146	positive regulation of fibroblast proliferation
GO:0048705	skeletal system morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0051276	chromosome organization
GO:0051782	negative regulation of cell division
GO:0060070	canonical Wnt signaling pathway
GO:0071322	cellular response to carbohydrate stimulus
GO:0071347	cellular response to interleukin-1
GO:0071391	cellular response to estrogen stimulus
GO:0071464	cellular response to hydrostatic pressure
GO:0071966	fungal-type cell wall polysaccharide metabolic process
GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation
GO:1901857	positive regulation of cellular respiration
GO:2000573	positive regulation of DNA biosynthetic process
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001171	positive regulation of ATP biosynthetic process
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0005819	spindle
GO:0016604	nuclear body
GO:0030424	axon

Protein Structure and Domains

PDB ID

MGI:97250

InterPro

IPR002418 Transcription regulator Myc
IPR003327 Leucine zipper, Myc
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR012682 Transcription regulator Myc, N-terminal

PFAM

PF02344
PF00010
PF01056

PRINTS

PR00044

PIRSF

PIRSF001705

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References