InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD40

Summary

InnateDB Protein

IDBP-78916.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD40

Protein Name

CD40 molecule, TNF receptor superfamily member 5

Synonyms

Bp50; CDW40; p50; TNFRSF5;

Species

Homo sapiens

Ensembl Protein

ENSP00000361350

InnateDB Gene

IDBG-78904 (CD40)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Subcellular Localization

Isoform I: Cell membrane; Single-pass type I membrane protein.Isoform II: Secreted.

Disease Associations

Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269PubMed:11675497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

B-cells and in primary carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	64 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006461	protein complex assembly
GO:0006874	cellular calcium ion homeostasis
GO:0030168	platelet activation
GO:0032855	positive regulation of Rac GTPase activity
GO:0042100	B cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050776	regulation of immune response
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0071260	cellular response to mechanical stimulus
GO:0090037	positive regulation of protein kinase C signaling
GO:2000353	positive regulation of endothelial cell apoptotic process